AKT1 (Proto-Oncogene) Antibody MBS439937 from MyBioSource.com

Product Specs
ItemAKT1 (Proto-Oncogene) Antibody
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS439937
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ApplicationsImmunohistochemistry (IHC) Formalin
Conjugate/TagUnconjugated
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ReactivityHuman. Others not known
TargetAKT1
IsotypeIgG2b kappa
Molecular Weight62kDa
CloneAKT1/2491
HostMouse
ImmunogenRecognizes a protein of 62kDa, which is identified as AKT1The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKB? or RacPK-?) and Akt 3 (also designated PKB? or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a Pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-? tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1(IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s), and the activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin
NCBI Full Gene NameAKT serine/threonine kinase 1
NCBI Gene AliasesRAC, RAC-ALPHA, CWS6, PRKBA, AKT, PKB, PKB-ALPHA
ClonalityMonoclonal